Symbollon Pharmaceuticals, Inc. Evaluates The Clinical Effects Of IoGen(TM) On Fibrocystic Breast Disease

Iodine has been used as an
antimicrobial for the last century. Much has been written about molecular
iodine yet many women suffering from Fibrocystic Breast Disease (FBD) are
unaware that studies being conducted may soon yield an effective
nonhormonal treatment.



While there are several breast cancer drugs on the market, all
available hormonal therapies have significant adverse events. In contrast,
IoGen is a nonhormonal treatment that allows for safe long-term use with
little or no side effects.



"Current research provides substantive support for the initiation of
human clinical studies on the use of molecular iodine as a treatment for
breast disease," stated Paul Desjourdy, President and CEO, Symbollon
Pharmaceuticals, Inc. "The possibility that IoGen may be used as a
treatment for breast cancer makes it all the more important that we
expedite the commercialization time line."



The Company believes IoGen has the ability to eliminate excess cell
growth in female reproductive tissue, including the breast, ovaries and
uterus. Other indications for IoGen include the treatment or prevention of
endometriosis, ovarian cysts, and premenopausal breast cancer.



Symbollon Pharmaceuticals, Inc. is now in FDA Phase III clinical trials
for the evaluation of IoGen (I2) for pain/tenderness associated with FBD
and with potential to treat female reproductive organ cancers.



The importance of (I2) in the treatments for mammary gland dysfunctions
has been corroborated in human and animal models.



Seaweeds, containing high quantities of iodine in several chemical
forms including (I2), have been associated with low incidences of benign
and malignant breast disease in Asian women.



Past studies by independent researchers have supported the possible
effectiveness of molecular iodine (I2) as a treatment for breast cancer.


-- Researchers at Drexel University College of Medicine found that
molecular iodine alters the gene expression profile in the human breast
cancer cells. Dr. Bernard Eskin remarked that these changes may be
responsible for molecular iodine's inhibition of breast cancer
promotion that has been repeatedly observed in animal models.


-- Some researchers investigating the connection between breast tissue and
iodine observed that frequent childbirth and a long lactation period
are known to reduce the risk of breast cancer.



Symbollon is now conducting its IoGen (I2) Phase III pivotal pain
study. Results are expected in first quarter of 2008. For more information
on IoGen(TM), please visit the company's web site at: symbollon or
mybreastpain.


Symbollon Pharmaceuticals, Inc.

symbollon